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is a selective LIM kinase 2 (LIMK2) inhibitor
12 cells (EC50 ~ 4 nM) and RS4
3-3 mg/kg once day in mouse models
Fenretinide (4-HPR) exerts not just acute but also long term antitumor activity in selected T-ALL cell lines
PAI-039 - CAS# 393105-53-8 size:2mg solid is a selective LIM kinasePAI 039, CAS No. 393105 53 8, is a novel plasminogen activator inhibitor 1 (PAI 1) inhibitor. The pharmacokinetic profile of PAI 039 indicated an oral bioavailability of 43 + 15. 3% and a plasma half life of 6. 2 + 1. 3 h. PAI 039 is an orally active prothrombolytic drug that inhibits PAI 1 and accelerates fibrinolysis while maintaining normal coagulation in a model of coronary occlusion . PAI 039 exerts antithrombotic efficacy in rat models of
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